AI Article Synopsis

  • The study aimed to explore the connection between maternal asthma symptoms and lung function with negative outcomes during pregnancy.
  • Asthmatic participants were monitored for lung function and asthma symptoms throughout their pregnancy, with data gathered on perinatal results post-delivery.
  • Findings indicated that lower lung function in pregnant women with asthma was linked to higher chances of gestational hypertension and preterm birth, while asthma symptom frequency did not show a significant impact on these outcomes.

Article Abstract

Objective: The purpose of this study was to test the hypothesis that maternal asthma symptoms and pulmonary function are related to adverse perinatal outcomes.

Study Design: Asthmatic patients were recruited from the 16 centers of the Maternal Fetal Medicine Units. Forced expiratory volume in 1 second was obtained at enrollment and at monthly study visits, and the frequency of asthma symptoms was assessed from enrollment to delivery. Perinatal data were obtained at postpartum chart reviews.

Results: The final cohort included 2123 participants with asthma. After adjustment for demographic characteristics, smoking, acute asthmatic episodes, and oral corticosteroid use, significant relationships were demonstrated between gestational hypertension and preterm birth and lower maternal gestational forced expiratory volume in 1 second. The data did not show any significant independent relationship between asthma symptom frequency and perinatal outcomes.

Conclusion: Lower pulmonary function during pregnancy is associated with increased gestational hypertension and prematurity in the pregnancies of women with asthma, which may be due to inadequate asthma control or factors that are associated with increased asthma severity.

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http://dx.doi.org/10.1016/j.ajog.2005.06.028DOI Listing

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