Anti-HBV nucleotide prodrug analogs: synthesis, bioreversibility, and cytotoxicity studies.

Bioorg Med Chem Lett

Spring Bank Technologies Inc., 113, Cedar Street, Suite S-7, Milford, MA 01757, USA.

Published: March 2006

Several pronucleotide analogs of the model anti-HBV dinucleotide 3'-dA-U(2'OMe) have been synthesized and evaluated for stability, bioreversibility and cytotoxicity. These studies have helped identify potential candidates for further evaluation.

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http://dx.doi.org/10.1016/j.bmcl.2005.12.058DOI Listing

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