AI Article Synopsis
- The study investigates how different doses of the influenza virus affect immune responses in mice.
- Researchers found that larger viral doses resulted in more weight loss, worse clinical scores, and increased mortality compared to smaller doses.
- Despite higher doses causing more severe disease, the immune response measured (like leukocyte influx and antibody levels) did not significantly change and was nearly maximal even at the lowest viral dose, suggesting that small doses can trigger effective immunity.
Article Abstract
How influenza virus dose affects the size of the immune response has not been clearly documented. Mice were challenged with three doses of influenza virus spanning a 100-fold range. Increasing the viral input dose increased the degree of weight loss observed, the clinical score and eventual mortality. Maximum viral loads increased with viral input and lower doses peaked and declined earlier. The level of the immune response only varied 2-fold and was independent of viral dose with near maximal responses elicited by the lowest dose, as measured by influx of antigen-specific and non-specific leukocytes into the lungs and by influenza antibody titers. We conclude that a strong immune response is mounted to a small dose of virus and curbs the spread of virus early and prevents weight loss whereas larger doses of virus elicit a slightly greater response but the associated disease can overwhelm the host.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.clim.2005.11.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!