The neuronal content of human thalamic nucleus reticularis was studied in serial sections cut in sagittal and frontal projections and impregnated with silver nitrate using Golgi method. The neuronal content of human thalamic nucleus reticularis was found to be more diverse than previously reported in animals and man. Besides two types of sparsely-branched long-dendritic spineless R1 and R2 neurons, this nucleus contained spiny cells. Medium and small-sized sparsely-branched short-dendritic neurons and densely-branched spiny cells were demonstrated. The principle of organization of human thalamic nucleus reticularis is described.
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J Neuroimaging
January 2025
Department of Otorhinolaryngology, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea.
Background And Purpose: Tinnitus is a condition in which individuals perceive sounds, such as ringing or buzzing, without any external source. Although the exact cause is not fully understood, recent studies have indicated the involvement of nonauditory brain structures, including the limbic system. We aimed to compare the volumes of specific brain structures between patients with tinnitus and controls.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Erasmus University Medical Center, Rotterdam, Zuid-Holland, Netherlands.
Background: Hippocampal volume is an acknowledged biomarker of neurodegenerative disease, including Alzheimer's disease (AD). However, the relationship between other subcortical brain structures and dementia risk is uncertain and may differ by disease stage. We aimed to assess the prognostic value of subcortical volumes for dementia risk across different disease stages by investigating memory clinic-based populations and community-dwelling individuals.
View Article and Find Full Text PDFBackground: Early alterations in the ventral tegmental area, a major brainstem dopaminergic nucleus, may be a marker of Alzheimer' disease (AD). However, how dopamine (DA) may influence neurofunctional and cognitive decline due to AD remains elusive. The aim of this study was to investigate alterations in resting-state functional connectivity (FC) associated with DA distribution in the brain along the AD continuum.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Erasmus University Medical Center, Rotterdam, Zuid-Holland, Netherlands.
Background: Hippocampal volume is an acknowledged biomarker of neurodegenerative disease, including Alzheimer's disease (AD). However, the relationship between other subcortical brain structures and dementia risk is uncertain and may differ by disease stage. We aimed to assess the prognostic value of subcortical volumes for dementia risk across different disease stages by investigating memory clinic-based populations and community-dwelling individuals.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Yale School of Medicine, New Haven, CT, USA.
Background: Affective cognition and emotion processing is impaired in amnestic Alzheimer's disease (AD), although less is known about atypical (AT) variants such as logopenic variant primary progressive aphasia (lvPPA) and posterior cortical atrophy (PCA). The affective blindsight pathway bypasses V1 via the superior colliculus-pulvinar route to activate the amygdala in cases of occipital lesioning and may explain maintenance of emotion identification and visual information processing in non-amnestic AD despite atrophy in visuospatial regions. We sought to characterize functional connectivity from key regions along the affective blindsight pathway in a clinically heterogeneous AD cohort.
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