Metronidazole (Mz)-resistant Giardia and Trichomonas were inhibited by 1 of 30 new 5-nitroimidazole drugs. Another five drugs were effective against some but not all of the Mz-resistant parasites. This study provides the incentive for the continued design of 5-nitroimidazole drugs to bypass cross-resistance among established 5-nitromidazole antiparasitic drugs.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1346785 | PMC |
| http://dx.doi.org/10.1128/AAC.50.1.344-347.2006 | DOI Listing |
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