AI Article Synopsis
- Brain trauma results in neuronal damage and loss, which can trigger an autoimmune response.
- Serum levels of IgG and IgM antibodies to beta-tubulin class III (betaTcIII), a protein found mainly in neurons, were monitored.
- In 15 out of 18 patients studied, the highest levels of these antibodies were detected within 3 weeks after the brain injury.
Article Abstract
Brain trauma typically leads to neuronal damage and loss. Assuming a transient autoimmune response to debris of the damaged neurones, we have monitored serum titres of IgG and IgM antibodies to beta-tubulin class III (betaTcIII), which is almost exclusively found in neuronal cytoskeletons. In 15 out of 18 patients, the peak of the IgG or IgM antibody titre appeared in the serum within 3 weeks of a brain trauma.
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| http://dx.doi.org/10.1016/j.brainresbull.2005.05.032 | DOI Listing |
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