AI Article Synopsis
- The murine forkhead family of transcription factors includes over 30 members crucial for embryonic development and involved in cell processes like proliferation and differentiation.
- In a study, specific forkhead genes were identified, particularly Foxj2, Foxk1, and the murine equivalent of the human ILF1 gene, which are preferentially expressed in complex cortical structures.
- Further analysis highlighted ILF1 as a new transcriptional regulator in dopamine neurons of the midbrain, suggesting these factors might be important for the maintenance and survival of both developing and adult neurons.
Article Abstract
The murine forkhead family of transcription factors consists of over 30 members, the vast majority of which is important in embryonic development. Implicated in processes such as proliferation, differentiation and survival, forkhead factors show highly restricted expression patterns. In search for forkhead genes expressed in specific neural systems, we identified multiple family members. We performed a detailed expression analysis for Foxj2, Foxk1 and the murine orthologue of the human ILF1 gene, which show a remarkable preference for complex cortical structures. In addition, a comprehensive examination of forkhead gene expression in dopamine neurons of the ventral tegmental area and substantia nigra pars compacta, revealed Ilf1 as a novel transcriptional regulator in midbrain dopamine neurons. These forkhead transcription factors may play a role in maintenance and survival of developing and adult neurons.
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| http://dx.doi.org/10.1016/j.brainres.2005.11.022 | DOI Listing |
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