We describe the asymmetric synthesis of the 5-amino-5-deoxy-l-fucose (l-fuco-nojirimycin) which appears as a very potent fucosidase inhibitor with a K(i) value of 1 nM.
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Tropos Diphenylmethane-Based Phosphine-Phosphoramidite Ligands: Design, Synthesis, and Application in Catalytic Asymmetric Hydrogenation.
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Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China.
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Tsinghua University, Chemistry, HeTian Building Dept. of Chemistry, Tsinghua University, Beijing, P. R. China, 100084, Beijing, CHINA.
Expanded heterohelicene composing of alternating linearly and angularly fused multi-resonance (MR) skeleton has garnered wide interest for their promising narrowband emission. Herein, a pair of sym- and asym-expanded heterohelicene isomers are firstly developed by merging boron/oxygen (B/O)-embedded MR triangulene and indolo[3,2,1-jk]carbazole units via one-shot synthesis. Owing to the fully resonating extended helical skeleton, the target heterohelicenes exhibit significantly narrowed spectra bandwidth while emission red-shifting, thus affording deep-blue narrowband emission with peak at around 460 nm, full-width-at-half-maximum (FWHM) of merely 18 nm and near-unity photoluminescence quantum yields.
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Osaka Research Institute of Industrial Science and Technology, 1-6-50 Morinomiya, Joto-ku, Osaka 536-8553, Japan.
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