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Prenatal cfDNA Sequencing and Incidental Detection of Maternal Cancer.
N Engl J Med
December 2024
From the Prenatal Genomics and Therapy Section, Center for Precision Health Research (A.E.T., D.W.B.), and the Section on Social Network Methods, Social and Behavioral Research Branch (J.L.), National Human Genome Research Institute, the Women's Malignancies Branch (C.M.A., I.S.G., P.S.R.) and the Cancer Data Science Laboratory (P.S.R.), Center for Cancer Research, National Cancer Institute, Radiology and Imaging Sciences, Clinical Center (A.A.M., B.R.), and the Office of the Director, Eunice Kennedy Shriver National Institute of Child Health and Human Development (D.W.B.), National Institutes of Health, Bethesda, and Leidos Biomedical Research, Frederick (M.P.) - both in Maryland.
Background: Cell-free DNA (cfDNA) sequence analysis to screen for fetal aneuploidy can incidentally detect maternal cancer. Additional data are needed to identify DNA-sequencing patterns and other biomarkers that can identify pregnant persons who are most likely to have cancer and to determine the best approach for follow-up.
Methods: In this ongoing study we performed cancer screening in pregnant or postpartum persons who did not perceive signs or symptoms of cancer but received unusual clinical cfDNA-sequencing results or results that were nonreportable (i.
Text Messaging Versus Postal Reminders to Improve Participation in a Colorectal Cancer Screening Program: Randomized Controlled Trial.
JMIR Mhealth Uhealth
January 2025
see Acknowledgments, .
Article Synopsis
- The study evaluated SMS text reminders for colorectal cancer screening in Catalonia, finding that they were less effective than standard postal reminders in increasing participation rates.
- The trial involved over 24,000 participants aged 50 to 69 and was halted early due to lower than expected participation in the SMS group (17.2% vs. 21.9% for control).
- Despite initial low participation, a recovery strategy of sending additional postal reminders to nonparticipants in the SMS group improved overall participation rates to 29.3%.
Adherence, risk perception, and attitudes towards colorectal cancer screening: A road to individualized screening?
Dig Liver Dis
December 2024
MEDCIDS, Faculty of Medicine, University of Porto, Portugal; Gastroenterology Department, RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) & Porto Comprehensive Cancer Centre (Porto.CCC), Porto, Portugal.
Background & Aims: Colorectal cancer (CRC) ranks second globally in cancer-related deaths and there is ongoing debate on the best populational screening strategy. This study aimed to evaluate individuals' intention to adhere to CRC screening, screening method preference, and barriers to screening.
Methods: Cross-sectional study conducted in northern Portugal, where a populational fecal occult blood test (FOBT) program is implemented.
Long-term outcome of the vaginoscopic approach for infantile vaginal yolk sac tumors: A case report.
Int J Surg Case Rep
December 2024
Department of Gynecology, Guangzhou Women and Children's Medical Center Liuzhou Hospital, Guangxi, China; State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China. Electronic address:
Introduction: Infantile vaginal yolk sac tumor (YST) is a rare and aggressive form of pediatric cancer that often presents with bloody discharge. Despite advances in chemotherapy, managing post-chemotherapy AFP level rebounds remains a challenge. This case report describes a 7-month-old girl with vaginal YST whose AFP levels rose following 3 cycles of PEB chemotherapy.
View Article and Find Full Text PDFCosts of colorectal cancer screening in Sweden: an observational, longitudinal cost description.
BMJ Open Gastroenterol
December 2024
Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Objective: Colorectal cancer (CRC) screening programmes have been implemented worldwide, but the evidence of the economic consequences of screening programmes relies on data from short-term trials. The aim of this paper was to describe the costs of CRC screening in a population-based screening programme, using administrative real-world data. Specifically, we aimed to estimate the annual costs of the screening programme and the total costs of the full programme over five consecutive screening rounds.
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