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Dermokine mutations contribute to epithelial-mesenchymal transition and advanced melanoma through ERK/MAPK pathways.
PLoS One
July 2023
Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
To discover vulnerabilities associated with dermokine (DMKN) as a new trigger of the epithelial-mesenchymal transition (EMT) -driven melanoma, we undertook a genome-wide genetic screening using transgenic. Here, we showed that DMKN expression could be constitutively increased in human malignant melanoma (MM) and that this correlates with poor overall survival in melanoma patients, especially in BRAF-mutated MM samples. Furthermore, in vitro, knockdown of DMKN inhibited the cell proliferation, migration, invasion, and apoptosis of MM cancer cells by the activation of ERK/MAPK signaling pathways and regulator of STAT3 in downstream molecular.
View Article and Find Full Text PDFHistone deacetylase inhibitor givinostat alleviates liver fibrosis by regulating hepatic stellate cell activation.
Mol Med Rep
May 2021
Department of Gastroenterology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, P.R. China.
Article Synopsis
- Hepatic fibrosis is a serious condition caused by chronic liver injury and is mainly linked to activated hepatic stellate cells (HSCs) that increase the extracellular matrix.
- The study focused on finding ways to inhibit HSC activation and discovered that the drug givinostat effectively suppresses HSC activation and alleviates liver fibrosis in mouse models.
- Givinostat treatment also highlighted key genes (dermokine, mesothelin, and uroplakin-3b) that are implicated in HSC activation, suggesting new targets for therapeutic interventions in liver fibrosis.
Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid model.
Wellcome Open Res
November 2019
Skin Research Group, Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, Scotland, DD1 9SY, UK.
Atopic eczema is an itchy inflammatory disorder characterised by skin barrier dysfunction. Loss-of-function mutations in the gene encoding filaggrin ( ) are a major risk factor, but the mechanisms by which filaggrin haploinsufficiency leads to atopic inflammation remain incompletely understood. Skin as an organ that can be modelled using primary cells provides the opportunity for selected genetic effects to be investigated in detail.
View Article and Find Full Text PDFHomeostatic Function of Dermokine in the Skin Barrier and Inflammation.
J Invest Dermatol
April 2020
Department of Dermatology, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan. Electronic address:
Dermokine is a chiefly skin-specific secreted glycoprotein localized in the upper epidermis, and its family consists of three splice variants in mice and five in humans. To investigate the pathophysiological impact of dermokine, we generated mice deficient for two (βγ) or all dermokine isoforms (αβγ). Both variants, especially dermokine αβγ-deficient mice exhibited scale and wrinkle formation resembling ichthyosis accompanied by transepidermal water imbalance at the neonatal stage.
View Article and Find Full Text PDFAnalysis of gene co‑expression network reveals prognostic significance of CNFN in patients with head and neck cancer.
Oncol Rep
April 2019
Department of Radiotherapy, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu 210000, P.R. China.
In patients with head and neck cancer (HNC), lymph node (N) metastases are associated with cancer aggressiveness and poor prognosis. Identifying meaningful gene modules and representative biomarkers relevant to the N stage helps predict prognosis and reveal mechanisms underlying tumor progression. The present study used a step‑wise approach for weighted gene co‑expression network analysis (WGCNA).
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