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Primary intracranial neuroendocrine tumor at the sphenoid ridge with metastasis to the spinal cord: A case report.

Medicine (Baltimore)

December 2024

Department of Neurosurgery, Xiamen Branch of West China Hospital, Sichuan University, Xiamen, P.R. China.

Rationale: Neuroendocrine tumors (NETs) originate from neuroendocrine cells and they are depicted with both nerve cells as well as hormone-producing cells. These tumors were initially discovered in extracranial locations and central nervous system involvement is often a result of metastasis. Herein, we present a very rare case of primary intracranial neuroendocrine tumor (PINET) that masqueraded as meningioma at the sphenoid ridge with metastasis to the spinal cord in a patient without a known history of extracranial NET at the time of diagnosis.

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Palato-Antral Involvement of a Primary Extracranial Sinonasal Meningioma.

Sultan Qaboos Univ Med J

November 2024

Department of ENT, GSL Medical College, Rajahmundry, India.

Article Synopsis
  • - Primary extracranial sinonasal meningiomas are extremely rare tumors in the head and neck area, with limited cases documented, particularly involving the palato-antral region.
  • - A 45-year-old male experienced nasal issues like frequent bleeding and blockage for 8 months, leading to a diagnosis of a meningioma that affected his palate; he underwent successful surgery using both intraoral and endoscopic methods.
  • - Post-surgery, the patient healed well and has shown no signs of recurrence for over two years; however, accurate diagnosis requires specific immunohistochemistry tests, and complete surgical removal is essential to prevent any recurrence or complications.
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Intracranial angioleiomyoma mimicking meningioma: an uncommon tumor with favorable outcome and frequent GJA4 mutation.

Neurosurg Rev

November 2024

Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Article Synopsis
  • Intracranial angioleiomyoma (IALM) is a rare brain tumor that resembles meningioma, accounting for about 10% of angioleiomyomas and predominantly affecting males, particularly in the orbital and cavernous sinus areas.
  • *The study analyzed 40 patients who underwent tumor resection and found that symptoms like vision impairment and diplopia were common, with a significant portion misdiagnosed as meningioma prior to surgery.
  • *Postoperative results indicated a clinically benign nature of IALM with no recurrence, and GJA4 mutations were noted in 42.5% of cases, correlating with progesterone receptor expression and suggesting a possible molecular link.
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Neuropathology Entities Involving the Sinonasal Tract.

Surg Pathol Clin

December 2024

Department of Pathology & Immunology, Division of Neuropathology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA. Electronic address:

Article Synopsis
  • Neuropathologic entities, though rare, can affect the sinonasal tract through different mechanisms including embryological defects and ectopic tissue remnants.
  • These entities may also arise from benign tumors that extend from the brain or nearby structures, such as pituitary adenomas and meningiomas.
  • Additionally, high-grade intracranial tumors like glioblastomas can invade the sinonasal area, making it essential for surgical pathologists to include these in the differential diagnoses of unusual sinonasal lesions.
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