AI Article Synopsis
- Three groups of six monkeys were infected with increasing doses of Campylobacter jejuni, resulting in 100% fecal colonization and varying degrees of diarrhea.
- The severity of diarrhea and duration of colonization decreased when the monkeys were challenged again after the initial infection.
- A. nancymae monkeys could be a valuable model for researching the effectiveness of vaccines against Campylobacter infections.
Article Abstract
Three groups of six monkeys (Aotus nancymae) each were inoculated intragastrically with increasing doses of Campylobacter jejuni. Infection resulted in fecal colonization (100% of monkeys), dose-related diarrhea, and robust immune responses. Colonization duration and diarrhea rate were reduced upon secondary challenge. A. nancymae may be useful for studying anti-Campylobacter vaccine efficacy.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1346678 | PMC |
| http://dx.doi.org/10.1128/IAI.74.1.790-793.2006 | DOI Listing |
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