CD8+ T cells have a protective role in experimental visceral leishmaniasis. However, the observation that inflammatory cytokines induce bystander activation of CD8+ T cells questions the need for antigen-dependent effector function. Here, we demonstrate that successful adoptive immunotherapy with CD8+ T cells is strictly dependent upon the presence of cognate antigen.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1346645PMC
http://dx.doi.org/10.1128/IAI.74.1.773-776.2006DOI Listing

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