The HtrA serine protease has been shown to be essential for bacterial virulence and for survival after exposure to many types of environmental and cellular stresses. A Listeria monocytogenes 10403S htrA mutant was found to be sensitive to oxidative and puromycin-induced stress at high temperatures, showed a reduced ability to form biofilms, and was attenuated for virulence in mice.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1346606 | PMC |
| http://dx.doi.org/10.1128/IAI.74.1.765-768.2006 | DOI Listing |
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