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Voluntary running exercise promotes maturation differentiation and myelination of oligodendrocytes around Aβ plaques in the medial prefrontal cortex of APP/PS1 mice.
Brain Res Bull
December 2024
Laboratory of Stem Cell and Tissue Engineering, Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, PR China; Department of Histology and Embryology, Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, PR China. Electronic address:
Background: Previous studies have reported that running exercise could improves myelinization in hippocampus. However, the effects of running exercise on the differentiation and maturation of oligodendrocytes, and myelination surrounding Aβ plaques in the medial prefrontal cortex (mPFC) of the Alzheimer's disease (AD) brain have not been reported.
Methods: Forty 10-month-old male APP/PS1 AD mice were randomly divided into the AD group and the AD running (AD+RUN) group, while 20 age-matched wild-type littermate mice were included in the WT group.
A novel 3D printing method for a notched eye plaque "dummy" for uveal melanoma brachytherapy.
Brachytherapy
November 2024
Department of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, PA; Ocular Oncology Service, Wills Eye Hospital, Philadelphia, PA.
Purpose: Suture preplacement by the ocular oncology surgeon is a critical step before inserting a radioactive plaque for ocular melanoma brachytherapy. We report on a novel 3D-printing method to create a custom "dummy" plaque applicator for the 22 mm notched gold plaque using in-house 3D-printing.
Methods: A computer-aided design (CAD) file was created replicating a heavily used gold plaque that no longer has a satisfactory "dummy" plaque.
Synthesis and preclinical evaluation of diarylamine derivative as Tau-PET radiotracer for Alzheimer's Disease.
Eur J Med Chem
January 2025
Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, 100875, China; Center for Advanced Materials Research, Beijing Normal University at Zhuhai, Zhuhai, 519087, China. Electronic address:
The presence of aggregated Tau in the brain is a dominant pathological hallmark of Tauopathies, particularly in Alzheimer's disease (AD). Therefore, developing ligands that can specifically and sensitively bind to Tau aggregates is essential for diagnosing and monitoring therapeutic interventions. In this study, we further investigated the structural optimization of the diarylamine skeleton, which exhibited promising binding characteristics and biological properties.
View Article and Find Full Text PDFInitial results of the Hyperion IIPET insert for simultaneous PET-MRI applied to atherosclerotic plaque imaging in New-Zealand white rabbits.
Phys Med Biol
October 2024
School of Biomedical Engineering & Imaging Sciences, King's College London, Department of Biomedical Engineering, St. Thomas' Hospital, Lambeth Road Palace, London, SE1 7EH, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
In preclinical research, in vivo imaging of mice and rats is more common than any other animal species, since their physiopathology is very well- known and many genetically altered disease models exist. Animal studies based on small rodents are usually performed using dedicated preclinical imaging systems with high spatial resolution. For studies that require animal models such as mini- pigs or New-Zealand White (NZW) rabbits, imaging systems with larger bore sizes are required.
View Article and Find Full Text PDFRadioimaging Foam Cells Infiltrating Atherosclerotic Plaques in Mice Using I-labeled oxLDL as a Radiotracer.
Mol Imaging Biol
December 2024
Joint Research Laboratory, Division of Integrated Pharmaceutical Sciences, Kyoto Pharmaceutical University, Misasagi, Yamashina-Ku, Kyoto, 607-8414, Japan.
Article Synopsis
- Bioimaging techniques like magnetic resonance are currently used to track atherosclerotic plaques made up of foam cells formed from macrophages that ingest oxidized low-density lipoprotein (oxLDL), but these methods lack specificity and sensitivity.
- This study tested iodine-125-labeled oxLDL (I-oxLDL) as a new radiotracer for better detection of foam cells in atherosclerotic plaques using various imaging techniques.
- Results showed that macrophages effectively took up I-oxLDL, allowing a notable radioactive signal to be detected in atherosclerotic plaques, indicating I-oxLDL's potential to enhance bioimaging techniques in the future.
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