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The associations of candidate gene polymorphisms with aspirin resistance in patients with ischemic disease: a meta-analysis.
Hum Genomics
December 2024
Department of Pharmacy, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing, China.
Article Synopsis
- Recent studies have focused on the link between genetic variations (polymorphisms) and aspirin resistance (AR) in patients with ischemic diseases, aiming to identify potential biomarkers for genetic testing before prescribing aspirin.
- The research involved analyzing 75 articles and evaluating 94 candidate gene polymorphisms, with 25 genes undergoing meta-analysis, revealing 23 significant associations with AR, including notable genes like PTGS2 and ITGA2.
- Subgroup analyses further highlighted specific genetic variations associated with AR across different populations, emphasizing the need for tailored approaches in aspirin therapy based on genetic profiles.
Investigation of the association between COX-2 polymorphisms and external apical root resorption in orthodontically treated patients.
Clin Oral Investig
December 2024
Postgraduate Program in Dentistry, School of Dentistry, Fluminense Federal University, Niterói, RJ, Brazil.
Article Synopsis
- This study investigates the link between specific genetic variations (SNPs) in the COX-2 gene and the occurrence of external apical root resorption (EARR) in patients after orthodontic treatment.* -
- Data was collected from 143 orthodontic patients, with analyses focusing on the maxillary central incisors and first mandibular molars, and two SNPs (rs5275 and rs689466) were genotyped using real-time PCR.* -
- Results show that patients carrying one copy of the G allele for SNP rs5275 have a significant increase in EARR for mandibular molars, suggesting that COX-2 genetic factors may influence the risk of root resorption during orthodontic care.*
Association between the variations in metabolic pathways and oral cancer risk: results from a Pakistani case-control study.
Mol Biol Rep
November 2024
Department of Zoology, GC University, Lahore, Pakistan.
Background: Oral cancer (OC) is a significant global health concern, with Pakistan ranking 5th worldwide in OC incidence. Given the poor prognosis, early detection of at-risk individuals is crucial. Genetic factors, particularly single nucleotide polymorphisms (SNPs) in metabolic genes, may influence OC susceptibility.
View Article and Find Full Text PDFIs infection protective against esophageal cancer?
World J Gastroenterol
October 2024
Department of General Medicine, College of Medicine and Sagore Dutta Hospital, Kolkata 700058, India.
() infection affects a substantial proportion of the global population and causes various gastric disorders, including gastric cancer. Recent studies have found an inverse relationship between infection and esophageal cancer (EC), suggesting a protective role against EC. This editorial focuses on the possible mechanisms underlying the role of infection in EC and explores the role of gut microbiota in esophageal carcinogenesis and the practicality of eradication.
View Article and Find Full Text PDFSex-dependent interaction of PTGS2 with miR-146a as risk factor for melanoma and the impact of sex hormones in gene expression in skin cells.
Melanoma Res
August 2024
Section of Biology and Genetics, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Strada Le Grazie, Verona.
Gender disparity in melanoma is a complex issue where sex hormones could be engaged. Differences in genetic variations are important in understanding the mechanisms of sex disparity in melanoma. Post-transcriptional regulation of prostaglandin-endoperoxide synthase (PTGS2) mRNA occurs through a complex interplay of specific trans-acting RNA-binding proteins and microRNAs.
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