Synthesis, physicochemical and pharmacokinetic characterization of calcium uronates.

J Inorg Biochem

Institute of Inorganic Chemistry and Metallurgy of Rare Elements, Faculty of Chemistry, University of Technology, Wybrzee wyspianskiego 27, 50-370 Wrocław, Poland.

Published: January 2006

AI Article Synopsis

  • Four calcium compounds with uronic acids were synthesized in specific ratios and characterized through various methods.
  • These methods included elemental analysis and different spectroscopic techniques, indicating thorough investigation of their properties.
  • The study revealed two types of water binding in the complexes and suggested that more research is necessary to assess the potential use of calcium uronates as calcium transporters.

Article Abstract

Four calcium compounds containing uronic acids (D(+)-galacturonic and D(+)-glucuronic) in L:M ratio = 2 and 3 were isolated by applying novel (except for one complex) synthetic procedures. The compounds were characterized by elemental analysis, spectroscopic methods (diffuse reflectance and absorption UV-visible, IR, FIR), mass spectrometry, fast atom bombardment (FAB), thermal decomposition, thermogravimetry/derivative thermogravimetry (TG/DTG) data and differential scanning calorimetric studies (DSC). Two modes of water binding in the complexes, i.e., hydration and coordination-like, were established. Computer-aided analysis has shown that further investigations are needed in order to determine the applicability of calcium uronates as calcium carriers.

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http://dx.doi.org/10.1016/j.jinorgbio.2005.10.012DOI Listing

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