Objective: To identify the clinical features and pathogenesis of hypoglycemia with brain dysfunctions as the main manifestations.
Method: A retrospective analysis of 73 cases with brain dysfunctions caused by hypoglycemia was performed.
Result: Hypoglycemic brain dysfunctions were mainly caused by poor control of the dosage of hypoglycemic agents in diabetic patients, and the major clinical manifestations included coma, hemiparalysis, epilepsy and mental disorders. The pathogenesis was complicated, possibly related to a variety of factors such as rapid declination of blood sugar level, aging, cerebral arteriosclerosis, and hypoglycemic cerebral vasospasm or selective nerve injury.
Conclusions: A blood sugar test should be performed for any patients with brain dysfunctions of unidentified causes for early diagnosis and treatment. In addition, diabetic patients should take hypoglycemic agent adequately. Regular monitoring of blood sugar level is key to the prevention of hypoglycemia.
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Neurotherapeutics
January 2025
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:
Extracorporeal membrane oxygenation (ECMO) is a technique used to support severe cardiopulmonary failure. Its potential life-saving benefits are tempered by the significant risk for acute brain injury (ABI), from both primary pathophysiologic factors and ECMO-related complications through central nervous system cellular injury, blood-brain barrier dysfunction (BBB), systemic inflammation and neuroinflammation, and coagulopathy. Plasma biomarkers are an emerging tool used to stratify risk for and diagnose ABI, and prognosticate neurofunctional outcomes.
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Department of Food Science and Nutrition, Hallym University, Chuncheon 24252, Republic of Korea. Electronic address:
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Department of Neurosurgery, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
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