Unlabelled: Metastases from primary laryngeal and hypopharyngeal cancers to cervical lymph nodes is of great importance in designing treatment schemes. The aim of this study was to explain: (1) Do site of primary tumor, its stage and histological differentiation have significant influence on formation metastases to lymphatic nodes of the neck; (2) Do the lymph nodes metastases influence on results of treatment?
Materials And Methods: We have analyzed records of 586 patients with advanced cancer of larynx and hypopharynx, who were treated by surgery between 1975 and 1990 in Department of Otolaryngology Medical University of Warsaw The clinical stages of cancer was defined according WHO classification (1987).
Results: cancer of the larynx was diagnosed in 477 cases and in 109 cases--of hypopharynx. The lymph nodes metastases were diagnosed in 152 (32%) cases with laryngeal carcinomas and in 97 (89%) cases with hypopharyngeal carcinomas. In every case the presence of unilateral metastases in lymphatic nodes of the neck was the reason of radical neck dissection, in bilateral metastases radical neck dissection was applied at one side of the neck and functional neck dissection on the second side.
Conclusions: Lymphatic metastases in laryngeal cancer are related to: site of primary tumor, extension of primary tumor and histologic differentiation. The metastases to lymph nodes in cancer of hypopharynx are diagnosed in the greater part, independently from progression of tumor. Presence of metastases in lymphatic nodes influence significantly on estimation of the treatment independently from progression of tumor. It was state that the best results give the method of combined treatment: the surgery and postoperative radiotherapy.
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Sci Rep
December 2024
Department of General Surgery, Chifeng Municipal Hospital, Inner Mongolia Medical University, Inner Mongolia, 024000, People's Republic of China.
Rectal cancer is a prevalent global malignancy. Recurrence and metastasis significantly impact patient survival over the long term. This study aims to identify independent risk factors associated with distant metastases in rectal cancer (RC) patients and develop a prognostic columnar-line diagram.
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L. Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolf Weigl 12, 53-114, Wroclaw, Poland.
Chronic lymphocytic leukemia (CLL) is prevalent in adults and is characterized by the accumulation of mature B cells in the blood, bone marrow, lymph nodes, and spleens. Recent progress in therapy and the introduction of targeted treatments [inhibitors of Bruton's tyrosine kinase (BTKi) or inhibitor of anti-apoptotic B-cell lymphoma-2 (Bcl-2i) protein (venetoclax)] in place of chemoimmunotherapy have significantly improved the outcomes of patients with CLL. These advancements have shifted the importance of traditional predictive markers, leading to a greater focus on resistance genes and reducing the significance of mutations, such as TP53 and del(17p).
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Department of Colorectal Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH. Electronic address:
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Department of Pharmaceutical and Biomedical Sciences College of Pharmacy, California Northstate University, 9700 West Taron Drive, Elk Grove, CA 95757, USA. Electronic address:
Complement C4 is a key component in the activation of classical and lectin complement pathways, which are observed in both animal tumor models and cancer patients. While its role in autoimmune disorders has been extensively studied, the functions of complement C4 and its activation in cancer have received inadequate consideration. Recent studies have detected C4 activation in animal tumor models and cancer patients, with its fragment C4d found in cancer tissues and lymph nodes.
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Department of Diagnostic Pathology, National Hospital Organization Shizuoka Medical Center, 762-1 Nagasawa, Shimizu, Sunto District, Shizuoka, 411-0904, Japan.
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