Highly efficient chromatographic resolution of alpha,alpha'-dihydroxybiaryls.

Org Lett

Department of Chemistry, Box 9573, Mississippi State University, Mississippi State, Mississippi 39762, USA.

Published: December 2005

[graph: see text] Separation factors as high as 115 were observed for the chromatographic resolution of many alpha,alpha'-dihydroxybiaryls with a single chiral stationary phase made from readily available amino acid derivatives. The stationary phase works well for biphenyl-type compounds. It works extremely well for larger bis-aromatic compounds, such as binaphthyl-type compounds.

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http://dx.doi.org/10.1021/ol052309zDOI Listing

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