Addition of a chiral copper reagent derived from propargylic oxazolidininone to aldehydes.

Org Lett

Laboratoire de Chimie Organique, UMR 761, Institut de Chimie Moléculaire FR 2769, Université Pierre et Marie Curie, 75252 Paris Cedex 05, France.

Published: December 2005

[reaction: see text] The copper reagent arising from an optically pure propargylic oxazolidinone was found to react regio- and diastereoselectively with aldehydes, leading, in a one-pot procedure, to the anti homopropargylic amino alcohols derivatives in good yields.

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Source
http://dx.doi.org/10.1021/ol0522743DOI Listing

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