The purpose of this study was to compare clinical probing measurements with the histologic alveolar bone level in an established baboon model. Implant sites were prepared by removal of all premolars and first molars in 10 adult female baboons (Papio anubis), a total of 120 sites. The resulting edentulous ridges were allowed to heal for 6 weeks. One implant was placed in each site and allowed to heal, after which the implants were removed en bloc. The animals were not sacrificed. Clinical probing from the implant platform to the crest of the bone was performed at the buccal and lingual aspects of each implant at the time of placement and prior to section removal. All measurements were taken with a calibrated probe by a single examiner (ARV). Sections were cut in a buccolingual plane through the long axis of each implant. Histologic slides were digitized for data collection, and histologic measurements were taken at the buccal and lingual aspects from the implant platform to the crest of the bone. The results of the study showed that there were no significant differences between the clinical and histologic measurements. The authors concluded that clinical measurements around dental implants are as reliable as histologic measurements and that the tip of the probe extended to the alveolar bone every time the implant was probed in this model.
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J Evid Based Integr Med
January 2025
Department of Biological Sciences, Faculty of Science, Beirut Arab University, Beirut, Lebanon.
Background: Polycystic Ovarian Syndrome (PCOS) is an endocrine disorder associated with increased risk of kidney and liver damage. Current treatments have shown contradictory outcomes, and their long-term use causes unwanted side effects. could serve as a complementary medicine to current PCOS treatments.
View Article and Find Full Text PDFCirc Heart Fail
January 2025
Aswan Heart Center, Magdi Yacoub Heart Foundation, Egypt (A.M.I., M.R., A. Elsawy, M.H., S.H., W.E., A. Elaithy, A. Elguindy, A. Afifi, Y.A., M.Y.).
Background: Changes in the phenotype and genotype in hypertrophic cardiomyopathy (HCM) are thought to involve the myocardium as well as extracardiac tissues. Here, we describe the structural and functional changes in the ascending aorta of obstructive patients with HCM.
Methods: Changes in the aortic wall were studied in a cohort of 101 consecutive patients with HCM undergoing myectomy and 9 normal controls.
BMC Pharmacol Toxicol
January 2025
Faculty of Medicine, Department of Physiology, Istanbul Demiroglu Bilim University, Istanbul, Turkey.
Background: Diabetic neuropathy (DN) is a heterogeneous condition characterized by complex pathophysiological changes affecting both autonomic and somatic components of the nervous system. Inflammation and oxidative stress are recognized contributors to the pathogenesis of DN. This study aims to evaluate the therapeutic potential of dichloroacetic acid (DCA) in alleviating DN symptoms, focusing on its anti-inflammatory and antioxidant properties.
View Article and Find Full Text PDFSci Rep
January 2025
Institute for X-ray Physics, Georg-August University Göttingen, Friedrich-Hund-Platz 1, 37077, Göttingen, Germany.
Imaging the entire cardiomyocyte network in entire small animal hearts at single cell resolution is a formidable challenge. Optical microscopy provides sufficient contrast and resolution in 2d, however fails to deliver non-destructive 3d reconstructions with isotropic resolution. It requires several invasive preparation steps, which introduce structural artefacts, namely dehydration, physical slicing and staining, or for the case of light sheet microscopy also clearing of the tissue.
View Article and Find Full Text PDFJAMA Cardiol
January 2025
National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital, London, United Kingdom.
Importance: Patients with transthyretin (ATTR) cardiac amyloid infiltration are increasingly diagnosed at earlier disease stages with no heart failure (HF) symptoms and a wide range of cardiac amyloid infiltration.
Objective: To characterize the clinical phenotype and natural history of asymptomatic patients with ATTR cardiac amyloid infiltration.
Design, Setting, And Participants: This cohort study analyzed data of all patients at 12 international centers for amyloidosis from January 1, 2008, through December 31, 2023.
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