AI Article Synopsis
- - New thiocolchicine derivatives (1-8) were created to be less toxic alternatives to colchicine while maintaining strong anticancer effects.
- - The process of synthesizing and evaluating the biological activity of these compounds was documented.
- - Initial in vitro tests indicated that compounds 1, 6, and 7 exhibited lower toxicity compared to colchicine and also demonstrated effective anticancer properties.
Article Abstract
New thiocolchicine derivatives (1-8) were designed as less toxic anticancer agents possessing the power full anticancer activity of colchicine. The synthesis and biological evaluation of these compounds were described. As a preliminary result of biological in vitro investigation, compounds 1, 6, and 7 showed lower toxicities than that of colchicine in combination with potent anticancer activities.
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| http://dx.doi.org/10.1002/ardp.200500148 | DOI Listing |
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