[Laryngeal carcinoid].

Vestn Otorinolaringol

Published: February 2006

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Article Synopsis
  • Laryngeal neuroendocrine neoplasms (LNENs) are uncommon and diverse malignant tumors, with the case presentation focusing on a patient diagnosed with a G2 Neuroendocrine Tumor (G2 NET) after multiple surgeries.
  • G2 NETs can sometimes be mistaken for hemangiomas due to their red and lumpy appearance, highlighting the need for better recognition among surgeons.
  • Effective treatment involves partial laryngectomy and neck lymph node dissection, as local resection has a high chance of relapse; accurate diagnosis relies on immunohistochemical methods.
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Article Synopsis
  • Neuroendocrine neoplasms (NENs) are uncommon in the head and neck, with laryngeal neuroendocrine carcinoma (NEC) being the most frequent, primarily affecting older men who smoke.
  • Approximately 700 cases have been documented, and the incidence rate is around 0.23%, leading to challenges in diagnosis and treatment due to their vague symptoms.
  • Treatment often combines surgery, chemotherapy, and radiotherapy, as illustrated by a case study of a 61-year-old female nonsmoker who received endoscopic excision and follow-up radiotherapy for supraglottic laryngeal NEC.
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Horizontal partial laryngectomy for laryngeal neuroendocrine tumor: A case report.

Int J Surg Case Rep

November 2024

Department of Otolaryngology-Head and Neck Surgery, Jichi Medical University, School of Medicine, Shimotsuke 329-0498, Japan. Electronic address:

Introduction: Moderately differentiated neuroendocrine tumors of the larynx are rare malignant tumors that arise from the submucosa of the larynx, for which surgery is the first-line treatment.

Presentation Of Case: We report a case of moderately differentiated neuroendocrine tumor of the larynx, in which the patient, a 74-year-old man, experienced long-term palliation but an unfortunate outcome of death owing to metastasis. Laryngeal endoscopic examination revealed an elevated submucosal lesion on the laryngeal surface of the epiglottis.

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Goblet cell adenocarcinoma.

Semin Diagn Pathol

September 2024

University of California San Diego, USA. Electronic address:

Appendix, considered a vestigial and disposable organ, has been long neglected as a source of abdominal tumors. Among the appendiceal tumors, goblet cell adenocarcinoma (GCA) is a rare primary epithelial neoplasm which has undergone multiple name changes and classifications in recent years, adding to confusion surrounding this unique amphicrine tumor. This entity was previously known as goblet cell carcinoid and adenocarcinoma ex goblet cell carcinoid.

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A man in his 80s with long-standing left-sided throat discomfort presented with hypophonia and odynophagia. A flexible nasoendoscopy revealed a supraglottic mass in the left arytenoid. An urgent microlaryngoscopy and biopsy demonstrated a supraglottic laryngeal tumour consistent with atypical carcinoid on histopathological examination.

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