AI Article Synopsis
- The study aimed to analyze the total dispersion of ventricular repolarization in the epi- and endocardium by recording monophasic action potentials (MAP) from various sites in the hearts of pigs during controlled pacing.
- Results indicated that the total dispersions of activation time, end of repolarization time, and MAP duration were significantly larger than those measured in individual layers, highlighting a notable difference in repolarization between the epi- and endocardium.
- The findings demonstrate that the mapping technique used for epicardial repolarization is effective, and both layers of the heart contribute significantly to overall repolarization dispersion.
Article Abstract
Objectives: To investigate the total dispersion of ventricular repolarization of the epi- and endocardium.
Design: Monophasic action potentials (MAP) were recorded from 211+/-54 (151-353) left and right ventricular epi- and endocardial sites during atrial pacing in 10 pigs using the CARTO system. The activation time (AT), MAP duration (MAPd) and end of repolarization time (EOR) were measured.
Results: The total dispersion of AT, EOR and MAPd, defined as the maximal differences of these parameters over both the epi- and endocardium, were 57+/-10, 84+/-20, and 75+/-21 ms respectively and were significantly larger than the respective epi- and endocardial dispersions (p<0.05). The epicardial dispersion of AT, EOR and MAPd of both the right and left ventricles were significantly larger than that of each ventricle alone (p<0.02). Sternotomy did not affect these dispersion parameters.
Conclusion: Detailed mapping of epicardial repolarization in vivo using the MAP mapping technique is feasible. Both the epi- and endocardium of the two ventricles contribute significantly to the total dispersion of repolarization.
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| http://dx.doi.org/10.1080/14017430500188744 | DOI Listing |
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