AI Article Synopsis
- Treatment of 2'-deoxyadenosine with acrolein at a specific temperature and pH creates unstable adducts with one or two fused ring systems.
- The reaction using 2'-deoxyadenosine produces at least four different diastereoisomers, complicating product identification.
- To simplify the analysis, 9-ethyladenine was used instead, and the products were characterized through UV, mass spectrometry, and NMR spectroscopy.
Article Abstract
Treatment of 2'-deoxyadenosine with acrolein at pH 4.6 in 37 degrees C affords unstable adducts containing either one or two fused ring systems where the hydroxypropano units are derived from acrolein. Since the use of 2'-deoxyadenosine resulted in the creation of at least four diastereoisomers for the adduct made up of two fused rings, therefore, for identification and assignment of the products, 9-ethyladenine was used instead as the starting material in the reaction. The products, 3E and 4E, were structurally characterised by UV, mass spectrometry and NMR spectroscopy.
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| http://dx.doi.org/10.1016/j.bioorg.2005.10.006 | DOI Listing |
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