Aim: To design and synthesize novel quinoxaline derivatives as antitumor agents.
Methods: Using 4-chloro-2-nitroaniline as a starting compound, followed by substitution, reductive cyclization, oxidation, and chlorination, to give the key intermediate 2,7-dichloroquinoxaline (7), which reacted with different phenolic compounds to afford quinoxaline derivatives.
Results: The structures of the target molecules were characterized by elemental analysis, 1H NMR, MS, and IR.
Conclusion: At concentration of 1 x 10(-4) mol x L(-1), some of the derivatives showed equal antitumor activities to XK469.
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