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A Chiral COFs Membrane for Enantioselective Amino Acid Separation.
Angew Chem Int Ed Engl
November 2024
College of Chemistry, Chemical Engineering and Materials Science, Jiangsu Key Laboratory of Advanced Functional Polymer Materials, & Suzhou key Laboratory of Macromolecular Design and Precision Synthesis, Soochow University, Suzhou, 215123, P.R. China.
Incorporating chiral molecules in the covalent organic frameworks (COFs) with uniformly ordered pores results in chiral COFs, which have been highly promising candidates for enantioseparation. Herein, a homochiral COF nanochannel membrane is reported by introducing chiral centers (L-phenylalanine methyl ester) into one of the organic ligands for the enantioseparation of chiral amino acids. The separation results show that the D-isomer is preferentially transported through the porous membrane channel.
View Article and Find Full Text PDFTemperature Sensitive Glutamate Gating of AMPA-subtype iGluRs.
bioRxiv
September 2024
Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that mediate the majority of excitatory neurotransmission. iGluRs are gated by glutamate, where upon glutamate binding, they open their ion channels to enable cation influx into post-synaptic neurons, initiating signal transduction. The structural mechanism of iGluR gating by glutamate has been extensively studied in the context of positive allosteric modulators (PAMs).
View Article and Find Full Text PDF2D Carbonaceous Materials for Molecular Transport and Functional Interfaces: Simulations and Insights.
Acc Chem Res
September 2024
Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, Tennessee 37235, United States.
Article Synopsis
- Advances in carbon-based two-dimensional (2D) materials, especially graphene, show promise for applications in chemical separations, catalysis, and energy storage by manipulating their structure at the atomic level.
- Key techniques for enhancing the functional properties of these materials include controlled stacking, ion gating, interlayer pillaring, and heterostructure charge transfer, which optimize gas permeation and selectivity.
- Computational simulations demonstrate the effectiveness of adjusting pore sizes and layer distances in porous graphene, enabling improved molecular separation and selective gas transport through innovative methods like the use of ionic liquids.
Sterolysin from a 1950s culture of Karlodinium veneficum (aka Gymnodinium veneficum Ballantine) forms lethal sterol dependent membrane pores.
Sci Rep
August 2024
Department of Chemistry, Morgan State University, Baltimore, MD, 21251, USA.
In 1957 Abbott and Ballantine described a highly toxic activity from a dinoflagellate isolated from the English Channel in 1949 by Mary Park. From a culture maintained at Plymouth Laboratory since 1950, we have been able to isolate two toxic molecules (abbotoxin and 59-E-Chloro-abbotoxin), determine the planar structures by analysis of HRMS and 1D and 2D NMR spectra, and found them to be karlotoxin (KmTx) congeners. Both toxins kill larval zebrafish with symptoms identical to those described by Abbot and Ballantine for gobies (Gobius virescens).
View Article and Find Full Text PDFMolecular mechanism of anion permeation through aquaporin 6.
Biophys J
August 2024
Department of Pharmacology, Keio University School of Medicine, Tokyo, Japan.
Aquaporins (AQPs) are recognized as transmembrane water channels that facilitate selective water permeation through their monomeric pores. Among the AQP family, AQP6 has an intriguing characteristic as an anion channel, which is allosterically controlled by pH conditions and is eliminated by a single amino acid mutation. However, the molecular mechanism of anion permeation through AQP6 remains unclear.
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