The vascular wall as a regulator of tissue oxygenation.

Curr Opin Nephrol Hypertens

Department of Bioengineering 0412, University of California-San Diego, La Jolla, CA 92093, USA.

Published: January 2006

Purpose Of Review: The development of the phosphorescence quenching oxygen measurement technique has allowed for a simultaneous measurement of intra and perivascular partial pressure oxygen along arteriolar vessels in vivo. Mapping the microvascular distribution and oxygen gradients across the vascular walls using this high-resolution technique reveals the existence of large radial gradients between the vasculature and the tissue, with concomitant longitudinal oxygen loss. Mass balance analysis along vessel segments indicates that the vascular wall has a high rate of oxygen consumption. This review presents the current status of in-vivo studies on the partitioning of oxygen between blood, the vascular wall and the surrounding tissue, thereby positioning an oxygen sink between blood and tissue regulating oxygen release.

Recent Findings: Induced vasoactivity (vasoconstriction and vasodilation) has been shown to modulate oxygen consumption of the vascular wall and directly affect the portion of oxygen available to the tissue. Inhibition of the endothelial layer of the vessel wall resulted in a decrease in the oxygen gradient across the vessel.

Summary: The vascular wall is a sink for oxygen. The modulation of vessel wall oxygen consumption can substantially impact the amount of oxygen released to the tissue.

Download full-text PDF

Source
http://dx.doi.org/10.1097/01.mnh.0000196147.65330.a3DOI Listing

Publication Analysis

Top Keywords

vascular wall
20
oxygen
14
oxygen consumption
12
vessel wall
8
vascular
6
tissue
6
wall
6
wall regulator
4
regulator tissue
4
tissue oxygenation
4

Similar Publications

Radiotherapy is the main treatment for patients with head and neck cancer (HNC) and is associated with an increased risk of ischemic cerebrovascular events (ICVE). The purpose of this cross-sectional study was to determine the incidence of ICVE and carotid artery stenosis (CAS) in patients with HNC who receive radiotherapy and the risk factors for CAS. We enrolled 907 patients with HNC who underwent radiotherapy between February 2011 and June 2022 and obtained information on their clinical and tumor characteristics and their treatment from the clinical records.

View Article and Find Full Text PDF

Aims: Image-based, patient-specific rupture risk analysis of AAAs is promising but it is limited by invasive and costly imaging modalities. Ultrasound (US) offers a safe, more affordable alternative, allowing multiple assessments during follow-up and enabling longitudinal studies on AAA rupture risk.

Methods And Results: This study used time-resolved three-dimensional US to assess AAA rupture risk parameters over time, based on vessel and intraluminal thrombus (ILT) geometry.

View Article and Find Full Text PDF

Delayed Superficial Temporal Artery Pseudoaneurysm Following Minor Trauma in a Post-facelift Patient.

J Craniofac Surg

January 2025

College of Medicine, Ewha Womans University, Department of Plastic and Reconstructive Surgery, Ewha Womans University Seoul Hospital, Seoul, Republic of Korea.

A 37-year-old woman with a history of facelift surgery presented with a painless temporal mass after surfboard trauma. Physical examination revealed a 1 cm pulsatile mass, and ultrasound confirmed a superficial temporal artery pseudoaneurysm. Surgical excision was complicated by adhesions from previous facial surgery and steroid injections.

View Article and Find Full Text PDF

Cardiomyocytes can be implanted to remuscularize the failing heart. Challenges include sufficient cardiomyocyte retention for a sustainable therapeutic impact without intolerable side effects, such as arrhythmia and tumour growth. We investigated the hypothesis that epicardial engineered heart muscle (EHM) allografts from induced pluripotent stem cell-derived cardiomyocytes and stromal cells structurally and functionally remuscularize the chronically failing heart without limiting side effects in rhesus macaques.

View Article and Find Full Text PDF

Objective: Thoracic outlet syndrome (TOS) is caused by compression of the neurovascular bundle at the thoracic outlet which often poses a diagnostic challenge. Patient management is often based on surgeon choice and experience. This study aims to describe practices relating to the diagnosis and management of TOS in the UK over a 1-year period.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!