AI Article Synopsis
- Cancer treatments that use thermal therapy and systemic therapies can trigger the production of heat shock proteins, which may reduce the effectiveness of the treatments.
- These heat shock proteins can inhibit cell death signaling and protect cells from damage, leading to poorer outcomes in cancer therapy.
- The paper reviews these treatments and suggests methods to minimize the stress response, potentially enhancing cancer treatment effectiveness by promoting more cell death (apoptosis) and tissue damage (necrosis).
Article Abstract
Cancer treatments that incorporate thermal therapy and some systemic therapies induce the production of heat shock or stress proteins. The induced heat shock proteins could lessen the effect of the therapy by inhibiting apoptotic signaling and by acting as molecular chaperones to prevent irreversible cellular damage. Strategies that prevent the induction of heat shock proteins would result in more apoptosis and necrosis, improving the cancer therapy. This paper briefly reviews cancer therapies that induce the stress response, and proposes strategies to reduce the stress response.
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| http://dx.doi.org/10.1080/02656730500331918 | DOI Listing |
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