Adherence of triamcinolone acetonide to various intraocular lens materials.

Purpose: To determine the adherence of triamcinolone acetonide to various intraocular lens (IOL) materials.

Setting: Department of Ophthalmology, Dokuz Eylül University, Izmir, Turkey.

Methods: Four IOLs of 4 materials (single-piece poly(methyl methacrylate) [PMMA], 3-piece foldable silicone, 3-piece hydrophobic acrylic, and single-piece hydrophilic acrylic) were first immersed in triamcinolone acetonide (40 mg/mL) for 15 minutes and then bathed in a balanced salt solution for another 15 minutes. Afterward, each lens optic was examined under light microscopy and digital images were obtained with a digital color video camera. The percentage of optic area covered with triamcinolone acetonide was determined by image analysis.

Results: Mean triamcinolone coverage was 7.62% +/- 4.06% (SD) for PMMA IOLs (range 1.97% to 11.43%), 9.09% +/- 4.60% for silicone IOLs (range 4.70% to 15.32%), 8.75 +/- 7.20% for hydrophobic acrylic IOLs (range 1.31% to 16.86%), and 23.16 +/- 8.53% for hydrophilic acrylic IOLs (range 15.02% to 35.12%). Adherence of triamcinolone acetonide to hydrophilic acrylic lenses was statistically significant when compared with other IOL materials.

Conclusion: Intraoperative triamcinolone injection may obscure visualization intraoperatively and postoperatively, especially in eyes with hydrophilic acrylic lenses, because triamcinolone acetonide seems to have a tendency to adhere to hydrophilic acrylic lenses in vitro.