AI Article Synopsis
- The study investigated alpha-tricalcium phosphate cements for repairing bone defects and their breakdown products in a lab setting.
- The researchers created bone defects in rabbits and implanted the cements, observing new bone growth and tissue changes over 12 weeks.
- The findings suggest that these cements are biocompatible, promote bone formation, and could be effective materials for bone reconstruction.
Article Abstract
Objective: This study was aimed to clarify the characteristics of alpha-tricalcium phosphate cements in reconstructing bone defects and the action of degradation products of cements in vitro.
Methods: The defect (diameter 1.5 cm) was created in the calvaria of rabbit. Alpha-tricalcium phosphate cements were planted in the treatment groups. All groups were observed by histological examination and roentgenography. Bone marrow stromal cells (BMSc) were cultured in the degradation products of cements in vitro, and were observed by means of cytology and ALP.
Results: Degradation of artificial bone, new bone formation, and osteogenesis between artificial bone particles were observed at 12 weeks after implantation. Osteoinduction was observed in vitro.
Conclusion: Alpha-tricalcium phosphate cements have good biocompatibility, osteoinductivity and degradability, and are ideal bone substitute material for reconstruction.
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