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Characterizing astrocyte-mediated neurovascular coupling by combining optogenetics and biophysical modeling.
J Cereb Blood Flow Metab
January 2025
Neuronal Mass Dynamics Lab, Department of Biomedical Engineering, Florida International, University, Miami, FL, USA.
Vasoactive signaling from astrocytes is an important contributor to the neurovascular coupling (NVC), which aims at providing energy to neurons during brain activation by increasing blood perfusion in the surrounding vasculature. Pharmacological manipulations have been previously combined with experimental techniques (e.g.
View Article and Find Full Text PDFResearch on virtual collection method of layer house temperature for the construction requirements of digital twin system.
Poult Sci
January 2025
Hebei Agricultural University, Baoding, Hebei 071000, China; Key Laboratory of Intelligent Equipment and New Energy Utilization in Livestock and Poultry Farming of Hebei Province, Baoding, Hebei 071000, China.
At present, in the context of the highly intensive development of livestock and poultry breeding, digital management is becoming increasingly important, and digital twin systems are gradually being applied. To solve the contradiction between data acquisition and sensor network congestion, a virtual acquisition method based on historical data and real-time reference of point data is proposed when constructing a digital twin system. Firstly, computational fluid dynamics (CFD) simulation was used to analyze and determine the temperature distribution and environmental characteristics inside the layer house, and the collection area was preliminarily divided according to the CFD simulation results.
View Article and Find Full Text PDFUnveiling structural components of dibenzofuran-based MMP-12 inhibitors: a comparative classification-dependent analysis with molecular docking-based virtual screening and molecular dynamics simulation.
In Silico Pharmacol
January 2025
Natural Science Laboratory, Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
Unlabelled: The implication of matrix metalloproteinase-12 (MMP-12) in various major disorders including cancer, COPD, cardiovascular disorders, and neurological diseases makes it a potential target for drug discovery. Contemplating the significance of MMP-12, a number of MMP-12 inhibitors were designed, synthesized and tested throughout the world but the non-selective nature of most of those molecules can lead to adverse drug interactions. In contradiction, the dibenzofuran (DBF) and dibenzothiophene (DBT) derivatives showed highly potent and selective MMP-12 inhibition.
View Article and Find Full Text PDF[A short history of stroke].
Radiologie (Heidelb)
January 2025
Klinik für Diagnostische und Interventionelle Neuroradiologie, Universitätsklinikum des Saarlandes, Kirrberger Str., 66424, Homburg, Deutschland.
The history of stroke dates back to antiquity, where it was first described as "apoplexia" in Hippocratic writings. For centuries, understanding of the pathology was limited, based on Galen's theories and humoral pathology. Significant advances were made by Islamic scholars who expanded the knowledge and addressed existing contradictions.
View Article and Find Full Text PDFNew Insights into the Molecular Evolution of (Tapiridae, Perissodactyla) and the Rise and Fall of as a Full Species.
Genes (Basel)
November 2024
Department of Math Science and Technology, University of Minnesota Crookston, Crookston, MN 56716, USA.
Large wild mammals are extremely important in their respective ecological communities and are frequently considered to be emblematic. This is the case of the different tapir species, the largest terrestrial mammals from the Neotropics. Despite their large size and being objects of interest for many naturalists, the field still lacks critical genetics and systematics information about tapir species.
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