Objective: The study was aimed to evaluate the application of the quadrupole inductively coupled plasma mass spectrometer (ICP-MS) with collision/reaction cell octopole reaction system (ORS) to determine the iron stable isotope ratio in human fecal samples.
Methods: In a field trial on human metabolism, 3.0 mg per subject of iron with 57Fe enriched was orally administrated, and feces were collected by fecal monitoring. The isotope ratio of 57Fe to 56Fe in the prepared fecal sample was detected with the ORS-ICP-MS.
Results: With the application of ORS-ICP-MS, interferences from the Ar plasma and the calcium-contained polyatomic ions could be eliminated. When the sample solution properly diluted, interferences from the matrix were too little to be noted. The relative stand deviation (RSD) of the long-term and short-term precision was < 0.3 %. From the changes of 57 Fe/56 Fe in the daily samples, a regularity of fecal iron outputs was presented, and the fractional iron absorption could be evaluated.
Conclusion: The ratio of 57 Fe to 56 Fe in the fecal sample could be accurately determined by the quadrupole ICP-MS with ORS, based on which the dietary iron absorption could be evaluated and the metabolism of iron in the human body could also be traced.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
The importance of ion kinetic energy for interference removal in ICP-MS/MS.
Talanta
May 2024
Pacific Northwest National Laboratory, Richland, WA, 99352, USA. Electronic address:
The effect of ion kinetic energy on gas phase ion reactivity with ICP-MS/MS was investigated in order to explore tuning strategies for interference removal. The collision/reaction gases CO, NO and O were used to observe the ion product distribution for 48 elements using an Agilent tandem ICP-MS (ICP-MS/MS) as a function of reaction gas flow rate (pressure) and ion kinetic energy. The kinetic energy of the incident ion was varied by adjusting the octopole bias (V).
View Article and Find Full Text PDFReference intervals of 24 trace elements in blood, plasma and erythrocytes for the Slovenian adult population.
Clin Chem Lab Med
April 2024
Clinical Institute of Clinical Chemistry and Biochemistry, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Objectives: The aim of the present study was to establish the population- and laboratory-specific reference intervals (RIs) for the Slovenian adult population for 24 trace elements (TEs) in blood, plasma and erythrocytes and to evaluate the impact of gender, age, seafood consumption, smoking habits and amalgam fillings on TEs levels.
Methods: TEs (Mn, Co, Cu, Zn, Se and Mo, Li, Be, V, Cr, Ni, Ga, As, Rb, Sr, Ag, Cd, Sn, Cs, Au, Hg, Tl, Pb and U) were determined in 192 selected blood donors (107 women and 85 men, aged 18-65 years), using inductively coupled plasma mass spectrometry (ICP-MS) with the Octopole Reaction System. Participants filled out a questionnaire, and RIs were established according to the Clinical and Laboratory Standards Institute (CLSI) guidelines for TEs.
[Determination of toxic element concentrations in flour and cereal products by mass spectrometry with inductively coupled plasma].
Vopr Pitan
March 2023
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 614045, Perm, Russian Federation.
Systemic control and monitoring in the sphere of providing sanitary epidemiological welfare of population require routine procedures for determining toxic elements in variable foodstuffs. Their development is a pressing issue. Our research was to develop a procedure for determining concentrations of arsenic, cadmium, lead, mercury, aluminum and strontium in flour and cereal products by mass spectrometry with inductively coupled plasma.
View Article and Find Full Text PDFLevels and determinants of urinary cadmium in general population in Spain: Metal-MCC-Spain study.
Environ Res
July 2022
Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Instituto de Salud Carlos III, Av/Monforte de Lemos, 5, 28029, Madrid, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Instituto de Salud Carlos III. Av/Monforte de Lemos, 5, 28029, Madrid, Spain.
Background: Cadmium is a ubiquitous and persistent metal, associated with different harmful health effects and with increased morbidity and mortality. Understanding the main sources of exposure is essential to identify at risk populations and to design public health interventions.
Objective: To evaluate cadmium exposure in a random-sample of general adult population from three regions of Spain, assessed by the urinary cadmium (U-Cd) concentration, and to identify its potential determinants and sex-specific differences, including sociodemographic, lifestyle and dietary factors.
Study of the Reactivity of CHCOOH and COOH Ions with CHNH: Evidence of the Formation of New Peptide-like C(O)-N Bonds.
J Phys Chem A
November 2021
De la Molécule aux Nano-Objets: Réactivité, Interactions Spectroscopies, MONARIS, Sorbonne Université, CNRS, 75005 Paris, France.
Acetamide, a small organic compound containing a peptide bond, was observed in the interstellar medium, but reaction pathways leading to the formation of this prebiotic molecule remain uncertain. We investigated the possible formation of a peptide-like bond from the reaction between acetic acid (CH-COOH) and methylamine (CH-NH) that were identified in the interstellar medium. From an experimental point of view, a quadrupole/octopole/quadrupole mass spectrometer was used in combination with synchrotron radiation as a tunable source of VUV photons for monitoring the reactivity of selected ions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!