It was consider biological, molecular, biochemical and clinical aspects of a problem of an optimality. Examples of selective sensitivity of alive formations in relation to temperature of environment, ultraviolet and infa-red radiations, the contents of light negative aeroions. The gas preferendum phenomenon at animals and the person in relation to oxygen partial pressure in an inhabitancy is in details analysed. The data on evolution of gas structure of atmospheric air and a role of oxygen radicals in physiological and pathological processes are resulted. It is stated the actual material testifying to presence enough of powerful mechanisms of the adaptation vertebrales animals, but the limited opportunity to resist to high concentration of oxygen. The conclusion is made, that conditions moderately reduced Po2 provide the maximal activity physiological regeneration and can recommended for wider use in practice of clinical and out-patient rehabilitation.

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