Objective: The purpose of this study was to compare hemodynamic data derived from the transesophageal Doppler monitor (Medicina TECO, Berkshire, United Kingdom) against those obtained from a pulmonary artery catheter after coronary artery bypass grafting (CABG).
Design: Prospective, nonrandomized, clinical study.
Setting: Single, tertiary referral center.
Participants: Thirty-five adult patients.
Interventions: Cardiac output and hemodynamic variables were measured and compared at 4 predefined time points in patients undergoing elective off-pump CABG surgery from January 2003 through June 2003.
Measurement And Main Results: A total of 140 pairs for cardiac output (CO) data were obtained. Transesophageal cardiac output (TECO) values ranged from 1.9 to 8.7 L/min. Thermodilution cardiac output (TDCO) values ranged from 2.7 to 7.6 L/min. Matched measurements were made with each patient at intervals of 30 minutes. Bland-Altman analysis revealed a mean bias of 1.18 +/- 1.36 L/min, with a correlation (r) of 0.593 (p < 0.000) between TECO and TDCO. Similarly poor correlation was observed among cardiac index (r = 0.523), stroke volume (r = 0.615), systemic vascular resistance (r = 0.595), left ventricular stroke work index (r = 0.594), and right ventricular stroke work index (r = 0.590) measured by an esophageal Doppler monitor against a pulmonary artery catheter.
Conclusion: A transesophageal Doppler device (Medicina TECO) cannot be relied on as a sole method for monitoring cardiac output and derived hemodynamic variables in patients after CABG surgery.
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http://dx.doi.org/10.1053/j.jvca.2004.11.038 | DOI Listing |
Egypt Heart J
January 2025
Department of Cardiology, Division of Heart & Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.
Background: Hyponatremia is one of the complicating findings in acute decompensated heart failure. Decrease in cardiac output and systemic blood pressure triggers activation of renin-angiotensin-aldosterone system, antidiuretic hormone, and norepinephrine due to the perceived hypovolemia. Fluid-overloaded heart failure patients are commonly treated with loop diuretics, acutely decompensated heart failure patients tend to be less responsive to conventional oral doses of a loop diuretic, while other different diuretics could work in different part of nephron circulation system.
View Article and Find Full Text PDFJ Mol Cell Cardiol Plus
June 2024
Division of Pulmonary Circulation, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
Background: Pulmonary hypertension (PH) often leads to right ventricle (RV) failure, a significant cause of morbidity and mortality. Despite advancements in PH management, progression to RV maladaptation and subsequent failure remain a clinical challenge. This study explored the effect of paroxetine, a selective serotonin reuptake inhibitor (SSRI), on RV function in a rat model of PH, hypothesizing that it improves RV function by inhibiting G protein-coupled receptor kinase 2 (GRK2) and altering myofilament protein phosphorylation.
View Article and Find Full Text PDFJ Cardiovasc Pharmacol Ther
January 2025
Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, USA.
Background: Neurohormonal blocking drugs, like beta-blockers, angiotensin-converting enzyme inhibitors (ACEIs), and angiotensin receptor blockers (ARBs), are recommended for treating anthracycline-induced left ventricular dysfunction (AILVD). However, there is limited evidence supporting their benefit. Therefore, this study evaluated associations of neurohormonal blockers and other clinical factors with recovery of left ventricular ejection fraction (LVEF) in patients with AILVD.
View Article and Find Full Text PDFAnn Intensive Care
January 2025
Service de Médecine Intensive-Réanimation, Hôpital de Bicêtre, DMU CORREVE, Inserm UMR S_999, FHU SEPSIS, Groupe de Recherche Clinique CARMAS, Université Paris-Saclay, AP-HP, Le Kremlin-Bicêtre, France.
Background: Excessive tachycardia is associated with impaired hemodynamics and worse outcome in critically ill patients. Previous studies suggested beneficial effect of β-blockers administration in ICU patients, including those with septic shock. However, comparisons in ICU settings are lacking.
View Article and Find Full Text PDFCan J Cardiol
January 2025
Ted Rogers Centre for Heart Research, University Health Network, Toronto, ON, Canada; Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada. Electronic address:
Patients with cardiogenic shock (CS) present with critical hemodynamic compromise with low cardiac output (CO) resulting in end-organ dysfunction. Prognosis is closely related to the severity of shock and treatment of patients with CS is resource intensive. In this review, we consider the current treatment paradigms alongside the evidence that underpins them.
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