[Research of the relationship between smoking and peripheral arterial disease].

Zhonghua Yi Xue Za Zhi

Heart, Lung and Blood Vessel Center, Tongji University, Shanghai 200092, China.

Published: November 2005

Objective: To investigate the relationship between smoking and peripheral arterial disease (PAD) by investigate the smoking status and measuring the (ABI).

Methods: A questionnaire survey was conducted among 3379 male patients hospitalized in the departments of cardiovascular internal medicine, nephrology, and endocrinology, aged 40-98, 2253 smokers and 1126 non-smokers, to understand their life styles, anamnesis, and smoking history. All patients underwent measurement of systolic blood pressures of the upper arm and ankle so as to calculate the ankle-brachial index (ABI). Measurement. An ABI less than or equal to 0.9 was considered to be indicative of significant PAD.

Results: The ABI levels in the smoker group were significantly lower than those in the non-smoker group (P < 0.05). The prevalence of PAD was 24.94% in the smoker group, and 20.60% in the non-smoker group. The age-adjusted OR of the smokers was 1.480 (95% CI: 1.237-1.770), with a significant dosage-effect relationship between smoking and PAD.

Conclusion: Smoking is a significant risk factor of PAD. The prevalence of PAD was increased with the dosage of smoking.

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