Facile and efficient postsynthetic tritium labeling method catalyzed by Pd/C in HTO.

J Org Chem

Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1, Mitahora-higashi, Gifu, 502-8585, Japan.

Published: December 2005

[reaction: see text] We have developed a facile and efficient tritium labeling method using a Pd/C-HTO-H2 system. This method can provide multitritium-labeled compounds in highly diluted HTO under T2 gas-free conditions, and is environmentally benign since purification by silica gel column chromatography is not necessary, which causes a large quantity of radioactive waste such as silica gel and eluent.

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http://dx.doi.org/10.1021/jo0517545DOI Listing

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