Optically active (S)-2-ethylphenylpropanoic acid derivatives, dual agonists for human peroxisome proliferator-activated receptor (PPAR) alpha and delta, were efficiently prepared by using Evan's chiral oxazolidinone technique and reductive amide N-alkylation as key steps.
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Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivatives: dual agonists for human peroxisome proliferator-activated receptor alpha and delta.
Bioorg Med Chem Lett
February 2006
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Optically active (S)-2-ethylphenylpropanoic acid derivatives, dual agonists for human peroxisome proliferator-activated receptor (PPAR) alpha and delta, were efficiently prepared by using Evan's chiral oxazolidinone technique and reductive amide N-alkylation as key steps.
View Article and Find Full Text PDFEfficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivative, a selective agonist for human peroxisome proliferator-activated receptor alpha.
Bioorg Med Chem Lett
August 2002
Discovery Research Laboratories, Kyorin Pharmaceutical Co., Ltd., 2399-1Mitarai, Nogi-machi, Shimotsuga-gun, 329-0114, Tochigi, Japan.
An optically active phenylpropanoic acid derivative, a selective agonist for human peroxisome proliferator-activated receptor alpha, was efficiently prepared in high optical purity by using Evans chiral oxazolidinone technique as a key step.
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