The absorption of a photon by a photoreceptor triggers a small voltage fluctuation termed the 'bump'. Here, in the housefly, I introduce the bispectrum of photoreceptor noise to characterise the bump under dim light. The bispectrum provides explicit phase information and is not contaminated by Gaussian background noise. Over the photon rates examined (<10(4) s(-1)), I show that bumps are minimum-phase, noise spectra are little affected by natural variations in bump shape and bumps adapt such that amplitude is approximately proportional to duration squared. In the dark exists a 'dark event', which I suggest represents spontaneous activation of G-protein.
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http://dx.doi.org/10.1016/j.visres.2005.09.020 | DOI Listing |
J Transl Med
January 2025
Department of Medical Oncology, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Anhui Provincial Cancer Hospital, Hefei, 230031, Anhui, China.
Background: Agonistic monoclonal antibodies targeting 4-1BB/CD137 have shown preclinical promise, but their clinical development has been limited by severe liver toxicity or limited efficacy. Therefore, a safe and efficient immunostimulatory molecule is urgently needed for cancer immunotherapy.
Methods: A novel anti-MSLN×4-1BB bispecific antibody (bsAb) was generated via antibody engineering, and its affinity and activity were detected via enzyme-linked immunosorbent assay (ELISA), flow cytometry, and T-cell activation and luciferase reporter assays.
J Public Health Policy
January 2025
Denver Health and Hospital Authority, 601 Broadway, 7th Floor, Denver, CO, 80203, USA.
In the United States and within Colorado, the number of persons experiencing homelessness has risen, with over 600,000 counted on a single night in 2023. Limited data integration across healthcare and social services hinders understanding of how permanent supportive housing (PSH) affects health outcomes. Our study in partnership with healthcare experts, housing providers, and a community advisory panel aimed to integrate data from health records, the justice system, and housing case manager notes to create a multidimensional measure of PSH success.
View Article and Find Full Text PDFCommun Biol
January 2025
University of Chinese Academy of Sciences, 10049, Beijing, China.
Recent studies have unveiled the deep sea as a rich biosphere, populated by species descended from shallow-water ancestors post-mass extinctions. Research on genomic evolution and microbial symbiosis has shed light on how these species thrive in extreme deep-sea conditions. However, early adaptation stages, particularly the roles of conserved genes and symbiotic microbes, remain inadequately understood.
View Article and Find Full Text PDFLancet Infect Dis
January 2025
Barcelona Institute for Global Health, Barcelona, Spain; International Health Department, Hospital Clinic de Barcelona, Barcelona, Spain; Universitat de Barcelona, Barcelona, Spain. Electronic address:
Background: Treatments for soil-transmitted helminthiases face challenges, especially in addressing Trichuris trichiura. Combination regimens, particularly of ivermectin and albendazole, are promising. We aimed to assess the safety, efficacy, and palatability of a combination tablet for the treatment of T trichiura, hookworm, and Strongyloides stercoralis infections among school-aged children in Ethiopia, Kenya, and Mozambique.
View Article and Find Full Text PDFNanotechnology
January 2025
Experimentalphysik, Saarland University, Fachrichtung 7.2, Campus E2.6, 66123 Saarbruecken, Saarbrucken, Saarland, 66123, GERMANY.
Color centers are promising single-photon emitters owing to their operation at room temperature and high photostability. In particular, using nanodiamonds as a host material is of interest for sensing and metrology. Furthermore, being a solid-state system allows for incorporation to photonic systems to tune both the emission intensity and photoluminescence spectrum and therefore adapt the individual color center to desired properties.
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