[Expression of estrogen receptor and progesterone receptor in hilar cholangiocarcinoma and their clinical significances].

Objective: To investigate the relationship between the expression of estrogen receptor (ER) and progesterone receptor (PgR) and histological type, pathological grading and clinical staging in hilar cholangiocarcinoma (HCCA). To evaluate their roles in the development of it.

Methods: ER and PgR were assessed in 42 specimens of HCCA by immunohistochemical assay.

Results: The positive rate of ER and PgR was 66.7% and 64.3%. The expression of ER and PgR was significantly different between poor and well tumor differentiation, as well as between papillary and sclerosing variant.

Conclusion: The positive rate of ER and PgR was detected significantly in HCCA. They might be an important biological marker to evaluate the malignancy and prognosis of it.