The immune response of the primary tumor and regional lymph nodes was studied morphologically in 239 patients with vestibular cancer of the larynx. Marked infiltration of the stroma developed in 48, mild response or its absence were recorded in 97 patients. The difference in 5-year survival was significant (84 versus 62%). Out of 117 patients examined for B-dependent cortical and T-dependent paracortical response of the lymph nodes, 5-year survival in hyperplasia of the zones appeared to be 67%, in the absence of hyperplasia 42% and 44%, respectively. The difference is significant. The responses were essential for prognostication of the patient' survival.
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