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A Prospective, Open-Label, Randomized, Comparative, Investigator-Initiated Study to Evaluate the Safety and Effectiveness of Autologous Growth Factor Concentrate Using the Healrex Therapy Kit With Standard Wound Care in Lower-Extremity Diabetic Ulcer.
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Background and objectives The persistent nature of diabetic foot ulcers (DFUs) is mainly attributable to compromised wound healing mechanisms, which are aggravated due to poor blood flow, neuropathy, and infection. Growth factors have become essential agents in the treatment of DFUs, serving as primary mediators that enhance wound healing through the stimulation of cell proliferation, migration, and angiogenesis. This prospective open-label, randomised, comparative, multi-centre, investigator-initiated study compared the safety and effectiveness of adjuvant therapy with topical application of autologous growth factor concentrate (AGFC) using the Healrex therapy kit (Wockhardt, India) versus standard of care (SoC) in DFUs.
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Article Synopsis
- In May 2017, whole-genome sequencing became the main method for identifying bacterial strains in Canada, leading to the discovery of 16 multi-jurisdictional outbreaks linked to frozen raw breaded chicken products between 2017 and 2019.
- Of the 487 reported cases, there were 79 hospitalizations and 2 deaths, mainly involving individuals with a median age of 24 years, with the majority of outbreaks linked to a specific bacterial strain.
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