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Usefulness of mid-regional pro-adrenomedullin for stratifying risk in emergency department patients with solid tumors attended for febrile neutropenia secondary to chemotherapy.
Emergencias
December 2024
Servicio de Análisis Clínicos, Hospital Universitario Santa Lucía, Cartagena, Murcia, España.
Objective: To analyze the usefulness of mean mid-regional pro-adrenomedullin (MR-proADM) level to stratify risk in emergency department patients with solid tumors attended for febrile neutropenia after chemotherapy. To compare risk prediction with MR-proADM to that of conventional biomarkers and scores on the Multinational Association for Supportive Care in Cancer (MASCC) score.
Methods: Prospective observational cohort study enrolling patients with solid tumors who developed febrile neutropenia after chemotherapy.
COVID scientists as rhetorical citizens: Persuasive op-eds and public debate over science policy.
Public Underst Sci
January 2025
University of Washington, USA.
To discover the means of persuasion available to experts who embrace the responsibility of public communication in times of crisis, this study uses a text/countertext method of rhetorical analysis on U.S. newspaper editorials by scientists writing about COVID-19 policy.
View Article and Find Full Text PDFRetinal Inflammation and Reactive Müller Cells: Neurotrophins' Release and Neuroprotective Strategies.
Biology (Basel)
December 2024
Research and Development Laboratory for Biochemical, Molecular and Cellular Applications in Ophthalmological Science, IRCCS-Fondazione Bietti, via di Santo Stefano Rotondo 6, 00184 Rome, Italy.
Millions of people worldwide suffer from retinal disorders. Retinal diseases require prompt attention to restore function or reduce progressive impairments. Genetics, epigenetics, life-styling/quality and external environmental factors may contribute to developing retinal diseases.
View Article and Find Full Text PDFDietary nitrate supplementation very slightly mitigates the oxidative stress induced by high-intensity training performed in normobaric hypoxia.
Biol Sport
January 2025
Institute of Sport Sciences, University of Lausanne, Lausanne, Switzerland.
Oxidative stress is augmented under hypoxic environments, which may be attenuated with antioxidant supplementation. We investigated the effects of dietary nitrate (NO-) supplementation combined with high-intensity training performed under hypoxic conditions on antioxidant/pro-oxidant balance. Thirty trained participants were assigned to one of three groups - HNO: hypoxia (13% FO) + NO-; HPL: hypoxia + placebo; CON: normoxia (20.
View Article and Find Full Text PDFCucurbitacin IIb mitigates concanavalin A-induced acute liver injury by suppressing M1 macrophage polarization.
Int Immunopharmacol
January 2025
Institute of Immunology and Molecular Medicine, Jining Medical University, Jining 272067, China. Electronic address:
Cucurbitacins are a class of triterpenoid compounds extracted from plants and possess various pharmacological applications. Cucurbitacin IIb (CuIIb), extracted from the medicinal plant Hemsleya amabilis (Cucurbitaceae), has served as a traditional Chinese medicine for the treatment of bacterial dysentery and intestinal inflammation. CuIIb has been shown to exhibit anti-inflammatory activity; however, the protective effect of CuIIb against concanavalin A (Con A)-induced acute liver injury (ALI) and the fundamental mechanism remain unelucidated.
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