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Impact of hospital formulary intervention on carbapenem use: a segmented time-series analysis of consumption and a propensity score-matched non-inferiority study of treatment efficacy.
J Pharm Health Care Sci
January 2025
Laboratory of Clinical Pharmacy Education, Research and Education Center for Clinical Pharmacy, School of Pharmacy, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
Background: Pharmaceutical formularies play a crucial role in guiding medication use by balancing clinical effectiveness and cost efficiency. Although formulary implementation has been increasing in Japan, comprehensive evaluations of its impact on both clinical and economic outcomes are limited. This study aimed to assess the effect of introducing an antimicrobial formulary at Yokohama City University Hospital on antibiotic usage and treatment outcomes in intra-abdominal infections.
View Article and Find Full Text PDFTriple-drug antibiotic therapy for disseminated nocardial abscess in the mediastinum and brain of an immunocompetent patient: a case report.
BMC Infect Dis
January 2025
Department of Oncology, General Hospital of Western Theatre Command, No. 270, Tianhui Road, Rongdu Avenue, Jinniu District, Chengdu, Sichuan, 610000, People's Republic of China.
Background: Nocardia are widely present in nature and considered opportunistic pathogens. They can result in hematogenous spread infection through the ruptured skin or respiratory tract when the host's immune system is compromised. Currently, 119 species of Nocardia have been identified, with 54 capable of causing infections in humans.
View Article and Find Full Text PDFpulmonary disease with organizing pneumonia: A case report and review of literature.
Respirol Case Rep
January 2025
Department of Respirology, Graduate School of Medicine Chiba University Chiba Japan.
, a rapidly growing non-tuberculous mycobacterium, rarely causes pulmonary diseases. A patient was admitted to our hospital with a fever and cough. Chest radiography revealed consolidation in the right middle lung.
View Article and Find Full Text PDFMicroembolization Effects of Imipenem/Cilastatin In Vivo Depicted by Monochromatic Synchrotron X-Ray Microangiography.
J Vasc Interv Radiol
February 2025
Department of Radiology, Kawasaki Medical School, Kurashiki City, Okayama, Japan.
Purpose: To elucidate the characteristics of imipenem (IPM)/cilastatin (CS) as an embolic material in microvessels in vivo.
Materials And Methods: Three healthy rabbits were injected subcutaneously in 1 auricle with picibanil (OK-432) in advance to create an inflammation-induced neovascular model. Microangiography was performed using monochromatic X-rays obtained from a large synchrotron radiation facility (SuperPhoton ring-8 GeV, SPring-8).
Imipenem-Cilastatin-Induced Seizures: A Case Report.
Curr Drug Saf
October 2024
Department of Pharmacy, Main Military Training Hospital of Tunis, Tunis, Tunisia.
Article Synopsis
- Imipenem-cilastatin, a carbapenem antibiotic, can cause rare side effects such as seizures, as highlighted by a case involving a 20-year-old male who experienced seizures and respiratory distress after its administration.
- Despite initial anti-epileptic treatment, seizures recurred until the antibiotic was discontinued, leading to the patient's stabilization, which suggests a link between the medication and the seizures.
- This case emphasizes the need for healthcare providers to recognize and monitor the potential neurological effects of imipenem-cilastatin, especially in vulnerable patients, and to consider both the benefits and risks when choosing antibiotics.
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