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Management of uncomplicated acute appendicitis: a protocol for systematic review and network meta-analysis of randomised-controlled trials.
BMJ Open
December 2024
Department of Emergency Medicine, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, People's Republic of China
Objectives: While multiple studies have shown the safety and efficacy of non-operative management, appendectomy remains the standard treatment for uncomplicated acute appendicitis (UAA). This study presents a protocol for a meta-analysis comparing antibiotic therapy, endoscopic retrograde appendicitis therapy (ERAT) and appendectomy in patients with UAA.
Methods And Analysis: We will conduct a systematic search of several databases, including PubMed, Web of Science, Embase, the China National Knowledge Infrastructure and the Cochrane Library.
The role of gut microbiota in the pathogenesis of diverticular disease: where are we now?
Genome Med
December 2024
Department of Medical and Surgical Sciences, Digestive Diseases Centre (CEMAD), Policlinico Universitario "A. Gemelli" Foundation, IRCCS, Rome, Italy.
Diverticular disease (DD) is widespread worldwide. The role of gut microbiota (GM) in DD is not entirely understood. Here we discuss the significance of the current knowledge on GM in the different stages of DD and how crucial these acquisitions are for designing diagnostic and therapeutic trials in this field.
View Article and Find Full Text PDFNeed for and update on clinical trials for uncomplicated type B aortic dissection.
JVS Vasc Insights
January 2024
Academic Department of Vascular Surgery, South Bank Section, School of Cardiovascular and Metabolic Medicine and Sciences, King's College London, British Heart Foundation Centre of Research Excellence, St Thomas' Hospital, London, UK.
The mainstay of management for uncomplicated type B aortic dissection is currently optimal medical therapy, targeting blood pressure and heart rate, along with serial imaging. There is a paucity of data that informs whether early intervention with thoracic endografting in this group of patients will promote aortic remodeling and better long-term outcomes. Investigations to date, including the Investigation of Stent Grafts in Aortic Dissection (INSTEAD), INSTEAD-XL, and Acute Dissection: Stent Graft or Best Medical Therapy (ADSORB) studies, have compared thoracic endovascular aortic repair (TEVAR) with optimal medical therapy in patients with uncomplicated type B aortic dissection but have not shown a benefit for TEVAR conclusively.
View Article and Find Full Text PDFVisual Endoscopic Retrograde Appendicitis Therapy vs Antibiotic Therapy for Treatment of Uncomplicated Acute Appendicitis.
Am J Gastroenterol
December 2024
Department of Gastroenterology, First Hospital of China Medical University, Shenyang, Liaoning, China.
Audit of a Novel Nurse-Led Program for Non-Antibiotic Management of Acute Uncomplicated Diverticulitis.
Dis Colon Rectum
December 2024
Department of Surgery, McGill University, Montreal, Quebec, Canada.
Background: Non-antibiotic outpatient treatment of acute uncomplicated diverticulitis is safe; however, uptake remains low.
Objective: To assess the success of non-antibiotic management of uncomplicated diverticulitis through a nurse clinician-led outpatient program.
Design: Retrospective audit from June 2022-March 2024.
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