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Microwave Freeze-thaw Technique for Injectable Drugs: A Review Updated from 1980 to 2021.
Int J Pharm Compd
November 2021
Medical Laboratory, CHU UCL Namur, Yvoir, Belgium.
The objective of this review was to collect information and results about the method of the microwave freeze-thaw treatment of injectable drugs and whether the method can support the development of Centralized Intravenous Admixtures Services. A systematic review of the scientific literature about injectable drug stability studies was performed. The data are presented in a table, which describes the name of the drug, producer, final concentration, temperature and time of freezing storage, type of microwave oven, thawing power, method of dosage, and the results after treatment or final long-term storage at 5°C ± 3°C.
View Article and Find Full Text PDFSpray dried nanospheres for inclusion complexes of cefpodoxime proxetil with β-cyclodextrin, 2-hydroxypropyl-β-cyclodextrin and methyl-β-cyclodextrin: improved dissolution and enhanced antibacterial activity.
Drug Dev Ind Pharm
August 2021
Faculty of Pharmacy, Department of Pharmaceutical Technology, Anadolu University, Eskişehir, Turkey.
Objective: The aim of the current research was the development hard cellulose capsules containing cefpodoxime proxetil (CEF) (BCS-Class II) encapsulated nanospheres of inclusion complexes with β-CD, HP-β-CD and M-β-CD for efficient antibacterial therapy.
Significance: The reason for this phenomenon is to bring an innovative approach to effective oral antimicrobial therapy with hard cellulose capsules containing spray dried nanospheres of CEF with β-CD, HP-β-CD and M-β-CD by means of increased solubility, dissolution rate and improved antibacterial efficiency with lower oral dose.
Methods: Phase solubility analyses was performed to evaluate the drug/CD interaction, involving the stoichiometry and apparent stability constant.
Physical Characterization and In Vitro Evaluation of Dissolution Rate from Cefpodoxime Proxetil Loaded Self Solidifying Solid SNEDDS.
Curr Drug Deliv
April 2022
Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Uttar Pradesh, India.
Background: Cefpodoxime Proxetil (CPD) is a broad-spectrum cephalosporin indicated in respiratory and urinary tract infections. CPD is a BCS class IV drug with pH-dependent solubility and has poor bioavailability. This study investigated the challenges of developing ternary components based on solid SNEDDS of CPD for in vitro dissolution rate enhancement and self-solidifying behaviour.
View Article and Find Full Text PDFStudy of the structure and dynamics at various parts of the antibacterial drug molecule cefpodoxime proxetil.
Solid State Nucl Magn Reson
October 2021
Physics Section, MMV, Banaras Hindu University, Varanasi, 221005, Uttar-Pradesh, India. Electronic address:
The structure and dynamics of cefpodoxime proxetil are elucidated by measuring chemical shift anisotropy (CSA) tensor, spin-lattice relaxation time, and local correlation time at twenty-one crystallographically different C nuclei sites. The principal components of CSA tensor of cefpodoxime proxetil are extracted by the two-dimensional phase adjusted sinning sideband (2DPASS) cross-polarization magic angle spinning (CP-MAS) solid-state NMR experiment, and the spin-lattice relaxation time is measured by the method outlined by Torchia(T1CP). The local correlation time is calculated by bearing in mind that the spin-lattice relaxation mechanism of C nuclei is mainly governed by the CSA interaction and the heteronuclear dipole-dipole interaction.
View Article and Find Full Text PDFRepurposing of cefpodoxime proxetil as potent neuroprotective agent through computational prediction and in vitro validation.
J Biomol Struct Dyn
July 2021
Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
In recent reports, NR2B-NMDA receptor antagonists showed more research value because of its strong targeting ability and less side effects potential. In 2016, EVT-101 was reported to bind in an almost entirely new binding region of this target. Whether strikingly different binding modes can improve targeting and reduce side effects is worth studying.
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