Test-specific effects of FG-7142 on isolation-induced aggression in mice.

Treatment with FG-7142 decreased isolation-induced attack, but not defense, by male mice when the residents' home cages contained only a sawdust substrate. When a small wooden nesting box was added to the cage (Experiment 2), however, FG-7142 somewhat increased levels of attack. Time spent in the nesting box was also increased, while overall levels of social interaction were decreased, by drug treatment in Experiment 2. The latter findings are consistent with FG-7142's well-documented anxiogenic properties and indicate that this drug is probably proaggressive in its actions. The antiaggressive effects of FG-7142 in Experiment 1 may have resulted from drug-induced fear behaviors that were incompatible with attack. Alternatively, Experiment 2 suggests the possibility that species-typical attack may be defensively motivated under some circumstances. Although the antiagressive properties of eltoprazine and yohimbine were unaffected by the addition of the nest box (Experiment 3), the provision of some sort of refuge within the testing apparatus may be an important methodological consideration for studies employing resident-intruder paradigms.