AI Article Synopsis
- A family of proteins known as CARDs is important for the immune response as they help detect virus infections and trigger antiviral defenses.
- Four studies identified a new CARD-containing protein, called IPS-1, MAVS, VISA, or Cardif, which is key for linking virus detection proteins (RIG-I and MDAS) to the immune response.
- If viruses like hepatitis C disrupt this signaling pathway, it may help them persist in the host's body.
Article Abstract
A growing family of cellular proteins encoding the caspase activation and recruitment domain (CARD) has a crucial role in immunity by sensing virus infection and signaling antiviral immune defenses. Four independent studies have identified a novel CARD-containing protein, variously called IPS-1, MAVS, VISA and Cardif, which is an essential signaling adaptor of the host defense mediating CARD-CARD interactions with retinoic acid inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDAS), sensors of virus infection. Disruption of this novel signaling pathway by hepatitis C virus (HCV) might provide a foundation for viral persistence.
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| http://dx.doi.org/10.1016/j.it.2005.11.004 | DOI Listing |
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