The isolation and structure elucidation of three new secondary metabolites, chaetoglobosin-510 (1), -540 (2), and -542 (3), are described. These compounds were produced by cultures of the marine-derived fungus Phomopsis asparagi, challenged with the known F-actin inhibitor jasplakinolide. Chaetoglobosin-542 (3) displayed antimicrofilament activity and was cytotoxic toward murine colon and leukemia cancer cell lines.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972004 | PMC |
| http://dx.doi.org/10.1021/np050293f | DOI Listing |
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